Roseanne Barr

(Roseanne Conner)

John Goodman

(Dan Conner)

Lecy Goranson

(Becky Conner-Healy)

Sara Gilbert

(Darlene Conner)

Michael Fishman

(D.J. Conner)

Laurie Metcalf

(Jackie Harris)

Natalie West

(Crystal Anderson Conner)

Gary Bayer

(Mr. Attleroy)