Roseanne Arnold

(Roseanne Conner)

John Goodman

(Dan Conner)

Laurie Metcalf

(Jackie Harris)

Lecy Goranson

(Becky Conner-Healy)

Sara Gilbert

(Darlene Conner)

Michael Fishman

(D.J. Conner)

Natalie West

(Crystal Anderson Conner)

Anne Faulkner

(Sylvia Foster)

Evelina Fernandez

(Juanita Herrera)

Charlaine Woodard

(Vonda)

Harper Roisman

(Joe)

Madge Sinclair

(Muriel)

Paco Vela

(Emilio)

Tom Wright

(Phil)