Iain Armitage

(Sheldon)

Zoe Perry

(Mary)

Lance Barber

(George Sr.)

Annie Potts

(Meemaw)

Montana Jordan

(Georgie)

Raegan Revord

(Missy)

Jim Parsons

(Adult Sheldon)

Ryan Phuong

(Tam)

Valerie Mahaffey

(Ms. Macelroy)

John Hartman

(Dr. Goetsch)

Christopher Cho

(Omar)