Iain Armitage

(Sheldon)

Zoe Perry

(Mary)

Lance Barber

(George Sr.)

Annie Potts

(Meemaw)

Montana Jordan

(Georgie)

Raegan Revord

(Missy)

Jim Parsons

(Adult Sheldon)

Matt Hobby

(Pastor Jeff)

Wallace Shawn

(Dr. Sturgis)

Ed Begley

(Dr. Linkletter)

Melissa Peterman

(Brenda Sparks)

Brian Stepanek

(Mr. Givens)

Sarah Baker

(Ms. Hutchins)

Ryan Phuong

(Tam)

Adrian Moreira-Behrens

(Donald)