Iain Armitage

(Sheldon)

Zoe Perry

(Mary)

Lance Barber

(George Sr.)

Annie Potts

(Meemaw)

Montana Jordan

(Georgie)

Raegan Revord

(Missy)

Jim Parsons

(Adult Sheldon)

Matt Hobby

(Pastor Jeff)

Jason Alexander

(Gene Lundy)

Ed Begley

(Dr. Linkletter)

Wendie Malick

(President Hagemeyer)

Steve Burns

(Nathan)

Melissa Peterman

(Brenda)

Brian Stepanek

(Mr. Givens)

Sarah Baker

(Ms. Hutchins)

Nancy Linehan Charles

(Peg)

Jackie Geary

(Ann)

Stephanie Escajeda

(Betty)