Rodney Dangerfield

(Thornton Melon)

Sally Kellerman

(Dr. Diane Turner)

Keith Gordon

(Jason Melon)

Burt Young

(Lou)

Robert Downey

(Derek Lutz)

Paxton Whitehead

(Dr. Phillip Barbay)

Terry Farrell

(Valerie Desmond)

M. Emmet Walsh

(Coach Turnbull)

Adrienne Barbeau

(Vanessa)

Ned Beatty

(Dean David Martin)

Severn Darden

(Dr. Borozini)

Sam Kinison

(Professor Terguson)

Robert Picardo

(Giorgio)

Kurt Vonnegut

()

Edie McClurg

(Marge Sweetwater)

Jason Hervey

(Young Thornton)