Harvey Keitel

(Jacob Fuller)

George Clooney

(Seth Gecko)

Quentin Tarantino

(Richard Gecko)

Juliette Lewis

(Kate Fuller)

Cheech Marin

(Border Guard/Chet Pussy/Carlos)

Fred Williamson

(Frost)

Salma Hayek

(Santanico Pandemonium)

Marc Lawrence

(Old Timer Hotel Owner)

Michael Parks

(Texas Ranger Earl McGraw)

Kelly Preston

(Newscaster Kelly Houge)

Tom Savini

(Sex Machine)

John Saxon

(FBI Agent Stanley Chase)

Danny Trejo

(Razor Charlie)

Ernest Liu

(Scott Fuller)

John Hawkes

(Pete Bottoms)