Helen Hunt

(Dr. JoAnne 'Jo' Thornton-Harding)

Bill Paxton

(William Harding)

Cary Elwes

(Dr. Jonas Miller)

Jami Gertz

(Dr. Melissa Reeves)

Lois Smith

(Meg Greene)

Alan Ruck

(Robert 'Rabbit' Nurick)

Philip Seymour Hoffman

(Dustin Davis)

Jeremy Davies

(Laurence)

Todd Field

(Tim 'Beltzer' Lewis)

Zach Grenier

(Eddie)

Nicholas Sadler

(Kubrick)

Abraham Benrubi

(Bubba)

Jake Busey

(Mobile Lab Technician)

Scott Thomson

(Jason 'Preacher' Rowe)

Eric LaRay Harvey

(Eric)