Nicolas Cage

(Cameron Poe)

John Cusack

(U.S. Marshal Vince Larkin)

John Malkovich

(Cyrus 'The Virus' Grissom)

Steve Buscemi

(Garland 'The Marietta Mangler' Greene)

Ving Rhames

(Nathan 'Diamond Dog' Jones)

Colm Meaney

(DEA Agent Duncan Malloy)

Mykelti Williamson

(Mike 'Baby-O' O'Dell)

Rachel Ticotin

(Guard Sally Bishop)

Monica Potter

(Tricia Poe)

Dave Chappelle

(Joe "Pinball" Parker)

M.C. Gainey

(Swamp Thing)

John Roselius

(Skip Devers)

Renoly

(Ramon Martinez)

Danny Trejo

(Johnny 'Johnny-23' Baca)

Jesse Borrego

(Francisco Cindino)

Nick Chinlund

(William 'Billy Bedlam' Bedford)

Angela Featherstone

(Ginny)

Jose Zuniga

(DEA Agent Willie Sims)

Landry Allbright

(Casey Poe)