William Hurt

(Mission Commander Professor John Robinson, Ph. D.)

Mimi Rogers

(Life Sciences Officer Maureen Robinson, Ph.D.)

Heather Graham

(Mission Medical Officer Judy Robinson, Ph.D.)

Lacey Chabert

(Video Mechanics Officer Penny Robinson)

Jack Johnson

(Robotics Officer Will Robinson)

Gary Oldman

(Base Physician Zachary Smith, Ph.D.)

Matt LeBlanc

(Flight Control Officer Major Don West)

Jared Harris

(Older Will Robinson)

Mark Goddard

(General)

Lennie James

(Jeb Walker)

Marta Kristen

(Reporter No. 1)

June Lockhart

(Principal Cartwright)

Edward Fox

(Business Man)

Adam Sims

(Lab Technician)

Angela Cartwright

(Reporter No. 2)

Dick Tufeld

(Rambler-Crane series Robot)