Denzel Washington

(Lincoln Rhyme)

Angelina Jolie

(Amelia Donaghy)

Queen Latifah

(Thelma)

Michael Rooker

(Captain Howard Cheney)

Mike McGlone

(Detective Kenny Solomon)

Luis Guzman

(Eddie Ortiz)

Leland Orser

(Richard Thompson/Marcus Andrews)

John Benjamin Hickey

(Dr. Barry Lehman)

Bobby Cannavale

(Steve)

Ed O'Neill

(Detective Paulie Sellitto)

Larry Day

(Gas Worker)