Lindsay Lohan

(Cady Heron)

Rachel McAdams

(Regina George)

Tina Fey

(Mrs. Norbury)

Tim Meadows

(Mr. Duvall)

Amy Poehler

(Mrs. George)

Ana Gasteyer

(Cady's Mom)

Lacey Chabert

(Gretchen Wieners)

Lizzy Caplan

(Janis Ian)

Daniel Franzese

(Damian)

Neil Flynn

(Cady's Dad)

Jonathan Bennett

(Aaron Samuels)

Amanda Seyfried

(Karen Smith)

Wai Choy

(Tim Pak)

Olympia Lukis

(Jessica Lopez)

Jonathan Malen

(Kristen's Boyfriend)

David Sazant

(Marymount Captain)

Elana Shilling

(Spelling Girl)