Mark Wahlberg

(John Bennett)

Mila Kunis

(Lori)

Seth MacFarlane

(Ted)

Joel McHale

(Rex)

Giovanni Ribisi

(Donny)

Patrick Warburton

(Guy)

Matt Walsh

(Thomas)

Jessica Barth

(Tami-Lynn)

Aedin Mincks

(Robert)

Bill Smitrovich

(Frank)

Patrick Stewart

()

Norah Jones

()

Sam J. Jones

()

Tom Skerritt

()

Brett Manley

(Young John)

Ralph Garman

(John's Dad)

Alex Borstein

(John's Mom)

John Viener

(Alix)

Laura Vandervoort

(Tanya)