Steve Carell

(Gru)

Kristen Wiig

(Lucy Wilde)

Benjamin Bratt

(Eduardo/El Macho)

Miranda Cosgrove

(Margo)

Russell Brand

(Dr. Nefario)

Steve Coogan

(Silas)

Ken Jeong

(Floyd)

Elsie Fisher

(Agnes)

Dana Gaier

(Edith)

Moises Arias

(Antonio)

Nasim Pedrad

(Jillian)

Kristen Schaal

(Shannon)

Pierre Coffin

(Kevin the Minio/Bob the Minion/Stuart the Minion)