Sandra Bullock

(Scarlet Overkill)

Jon Hamm

(Herb Overkill)

Michael Keaton

(Walter Nelson)

Allison Janney

(Madge Nelson)

Steve Coogan

(Professor Flux/Tower Guard)

Jennifer Saunders

(Queen Elizabeth II)

Geoffrey Rush

()

Pierre Coffin

(Kevin the Minion/Bob the Minion/Stuart the Minion/Additional Minions)

Steve Carell

(Young Gru)

Katy Mixon

(Tina)

Michael Beattie

(VNC Broadcaster/Highlight Reel Announcer/Walter Jr.)